基于YO:Eu稀土氧化物纳米颗粒的增强型切伦科夫发光断层扫描分析
Enhanced Cerenkov luminescence tomography analysis based on YO:Eu rare earth oxide nanoparticles.
作者信息
Gao Yongheng, Ma Xiaowei, Kang Fei, Yang Weidong, Liu Yi, Wang Zhengjie, Ma Wenhui, Wang Zhe, Li Guoquan, Cao Xu, Wang Jing
机构信息
Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xiâan 710032, China.
These authors contributed equally to this work.
出版信息
Biomed Opt Express. 2018 Nov 8;9(12):6091-6102. doi: 10.1364/BOE.9.006091. eCollection 2018 Dec 1.
Cerenkov luminescence imaging offers a new diagnostic alternative to radiation imaging, but lacks intensity and penetration. In this study, a Cerenkov luminescence signal and its image quality were enhanced using rare earth oxide nanoparticles as a basis for Cerenkov luminescence excited fluorescence imaging and Cerenkov luminescence excited fluorescence tomography. The results also provided 3D-imaging and quantitative information. The approach was evaluated using phantom and mice models and 3D reconstruction and quantitative studies were performed , showing improved optical signal intensity, similarity, accuracy, signal-to-noise ratio, and spatial distribution information. The method offers benefits for both optical imaging research and radiopharmaceutical development.
切伦科夫发光成像为放射成像提供了一种新的诊断替代方法，但存在强度和穿透性不足的问题。在本研究中，以稀土氧化物纳米颗粒为基础，增强切伦科夫发光信号及其图像质量，用于切伦科夫发光激发荧光成像和切伦科夫发光激发荧光断层扫描。结果还提供了三维成像和定量信息。使用体模和小鼠模型对该方法进行了评估，并进行了三维重建和定量研究，结果显示光信号强度、相似度、准确性、信噪比和空间分布信息均有所改善。该方法对光学成像研究和放射性药物开发均有益处。
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