School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Institute of Nanotechnology for Single Cell Analysis (INSCA), Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA.
Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Trends Biotechnol. 2019 Nov;37(11):1175-1188. doi: 10.1016/j.tibtech.2019.04.001. Epub 2019 May 6.
Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields.
可穿戴式医疗设备主要用于生物传感和经皮给药。可穿戴式生物传感器的最新进展使得能够以细胞分辨率长期实时监测生理状态。经皮药物输送系统进一步缩小，使各种货物（从天然分子（如胰岛素和葡萄糖）到生物工程分子（如纳米颗粒））的选择范围更广。一些新兴的纳米贴片显示出在体内进行精确单细胞基因转染的潜力，并且在递送效率、安全性和递送剂量的可控性方面优于传统工具。在这篇综述中，我们讨论了可穿戴式微/纳米设备在皮肤或其他器官中单细胞生物传感和转染方面的独特功能或潜力的最新技术进展，并为这些领域提出了未来的发展方向。
