Yazici Ahmet Bulent, Akcay Ciner Ozlem, Yazici Esra, Cilli Ali Savas, Dogan Burcu, Erol Atila
Sakarya University, Medical Faculty, Department of Psychiatry, Sakarya, Turkey.
Sakarya University, Medical Faculty, Department of Psychiatry, Sakarya, Turkey.
J Clin Neurosci. 2019 Jul;65:11-16. doi: 10.1016/j.jocn.2019.04.031. Epub 2019 May 7.
Schizophrenia (SCH) and drug addiction are chronic disorders that are frequently accompanied by physical diseases, poor nutrition and reduced self-care, all of which are likely to result in vitamin deficiencies. The objective of this study was to compare vitamin levels in SCH patients, substance use disorder (SUD) patients and healthy controls (HCs). The study included 189 SCH patients, 119 SUD patients and 109 HCs. Information on vitamin B12, folic acid and vitamin D levels were retrieved from the hospital's database, and mean values and deficiency/insufficiency were evaluated. Vitamin D deficiency (<30 ng/ml) was more common in the SCH group than in the SUD and HC groups (88.4%, 74.8% and 86.4%, respectively). Although there were no significant differences in folic acid deficiency (<3.0 ng/ml) in the SUD and SCH groups (15.1% and 8.5%, respectively), the incidence of folic acid deficiency was significantly higher in both groups as compared with that in the HC group (5.8%). Significantly higher numbers of patients in the SCH group than in the SUD group had vitamin B12 deficiency (45.5% vs. 28.3%). The prevalence of vitamin B12 deficiency in the SUD group was significantly higher than that the HC group (28.3% vs.11.5%). As compared with the HC group, vitamin D and B12 levels were significantly lower in SCH group, and folic acid and B12 levels were significantly lower in the SUD group. Several vitamin deficiencies appear to be common in both SCH and SUD. Possible reasons should be investigated.
精神分裂症（SCH）和药物成瘾是慢性疾病，常伴有身体疾病、营养不良和自我护理能力下降，所有这些都可能导致维生素缺乏。本研究的目的是比较精神分裂症患者、物质使用障碍（SUD）患者和健康对照者（HCs）的维生素水平。该研究纳入了189名精神分裂症患者、119名物质使用障碍患者和109名健康对照者。从医院数据库中获取维生素B12、叶酸和维生素D水平的信息，并评估其平均值以及缺乏/不足情况。维生素D缺乏（<30 ng/ml）在精神分裂症组比物质使用障碍组和健康对照组更为常见（分别为88.4%、74.8%和86.4%）。虽然物质使用障碍组和精神分裂症组的叶酸缺乏（<3.0 ng/ml）无显著差异（分别为15.1%和8.5%），但与健康对照组（5.8%）相比，两组的叶酸缺乏发生率均显著更高。精神分裂症组维生素B12缺乏的患者数量显著多于物质使用障碍组（45.5%对28.3%）。物质使用障碍组维生素B12缺乏的患病率显著高于健康对照组（28.3%对11.5%）。与健康对照组相比，精神分裂症组的维生素D和B12水平显著较低，物质使用障碍组的叶酸和B12水平显著较低。精神分裂症和物质使用障碍患者中似乎都存在几种常见的维生素缺乏情况。应调查其可能的原因。
