Childs J E, Korch G W, Glass G E, LeDuc J W, Shah K V
Am J Epidemiol. 1987 Jul;126(1):55-68. doi: 10.1093/oxfordjournals.aje.a114662.
Rats trapped from 14 locations in Baltimore, Maryland, were shown to have antibody to Hantavirus. Antibody prevalence rates were higher in residential locations than in parks. Infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection in urban rats in the United States. Prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired through age-related mechanisms. Three isolates of Hantavirus were obtained from rats. One of these isolates was shown by serologic tests and monoclonal antibody reactivity patterns to be similar, if not identical, to rat virus previously obtained from Philadelphia. The presence of rats in many urban settings and the high prevalence of Hantavirus infection in this species suggest that human exposure to this virus is occurring in the United States, although human disease from this exposure has not been recognized.
从马里兰州巴尔的摩市14个地点捕获的大鼠被证明感染了汉坦病毒。居民区的抗体流行率高于公园。在1980年至1985年的六年时间里，在五个地点持续捕获到感染的大鼠，这表明在美国城市大鼠中这种感染具有地方性流行的特性。抗体流行率和几何平均滴度随大鼠体重和性成熟度的增加而升高，这表明大鼠感染是通过与年龄相关的机制获得的。从大鼠中分离出三株汉坦病毒。其中一株通过血清学检测和单克隆抗体反应模式显示，即便与先前从费城获得的大鼠病毒不完全相同，也极为相似。许多城市环境中都有大鼠存在，且该物种中汉坦病毒感染的高流行率表明，在美国人类正在接触这种病毒，尽管尚未确认由此接触导致的人类疾病。
