Discipline of Pharmaceutical Sciences, College of Health Science, UKZN, Westville Campus, Durban, 4000, South Africa.
Discipline of Pharmaceutical Sciences, College of Health Science, UKZN, Westville Campus, Durban, 4000, South Africa.
Biosens Bioelectron. 2019 Jul 15;137:213-221. doi: 10.1016/j.bios.2019.03.065. Epub 2019 May 4.
Prostate cancer (PCa) is the most prevalent cancer with a high mortality rate. The early and accurate detection of PCa can significantly reduce mortality and saves lives. Hence, the nanomaterials based electrochemical nano-biosensors for PCa biomarkers will be the excellent alternative for diagnosis, detection and management of disease condition. In this review, we present a concise summary of the latest attainment and advancement in the use of nanoparticles for the diagnosis of PCa biomarkers. This review highlighted the importance of applying specific biomarkers along with nanomaterials like gold, magnetic, carbon nanotubes, and many other materials for developing electrochemical nanobiosensors in PCa detection. In addition to a summary on PCa detection, we further ensure future perspectives in PCa biomarkers detection, sensitivity, simplicity, rapidity, accuracy, cost-effectiveness and succeeding optimizations of novel technologies for more feasibility. Finally, closing remarks and an outlook conclude the review.
前列腺癌（PCa）是一种死亡率较高的最常见癌症。早期、准确地检测 PCa 可以显著降低死亡率，挽救生命。因此，基于纳米材料的电化学纳米生物传感器用于检测 PCa 生物标志物将是诊断、检测和管理疾病状况的绝佳选择。在本综述中，我们简要总结了纳米材料在 PCa 生物标志物诊断中的最新研究进展。本综述强调了应用特定生物标志物与纳米材料（如金、磁性、碳纳米管等）结合在开发用于 PCa 检测的电化学纳米生物传感器方面的重要性。除了对 PCa 检测的总结，我们还进一步确保了在 PCa 生物标志物检测、灵敏度、简单性、快速性、准确性、性价比和新型技术的后续优化方面的未来展望，以提高其可行性。最后，结束语和展望总结了综述。
