Strelkauskas A J, Callery R T, McDowell J, Borel Y, Schlossman S F
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5150-4. doi: 10.1073/pnas.75.10.5150.
These studies indicate that a regulatory subset of lymphocytes is missing in patients with juvenile rheumatoid arthritis but these patients have antibodies in their serum that react with normal T cells. This regulatory subset of T cells is, however, present in patients whose serum shows little or no reactivity with normal T cells. In addition, patients who are deficient in this regulatory subset of lymphocytes significantly higher numbers of cells secreting Ig as measured by a hemolytic plaque assay. The significance of these observations is twofold: first, they represent a positive relationship among the loss of regulation overproduction of immunoglobulin, and the presence of anti-T cell antibodies and second and perhaps of equal importance, is the indication that serum from patients with autoimmune diseases may give us a readily available reagent with which to dissect further functionally distinct subsets of normal T cells in man.
这些研究表明，幼年型类风湿性关节炎患者体内缺少一个调节性淋巴细胞亚群，但这些患者血清中有能与正常T细胞发生反应的抗体。然而，血清与正常T细胞几乎没有或没有反应性的患者体内存在这种调节性T细胞亚群。此外，缺乏这种调节性淋巴细胞亚群的患者，通过溶血空斑试验检测发现，分泌Ig的细胞数量明显更多。这些观察结果的意义有两方面：第一，它们代表了免疫球蛋白产生失控、抗T细胞抗体的存在以及调节缺失之间的正相关关系；第二，也许同样重要的是，这表明自身免疫性疾病患者的血清可能为我们提供一种现成的试剂，用以进一步剖析人类正常T细胞功能上不同的亚群。
