Notch 配体 DLL1 在人类乳腺癌细胞中发挥致癌作用。
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
机构信息
iBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal.
ITQB-Instituto de Tecnologia Química e Biológica, Oeiras, Portugal.
出版信息
PLoS One. 2019 May 20;14(5):e0217002. doi: 10.1371/journal.pone.0217002. eCollection 2019.
Abstract
These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.
摘要
这些发现进一步证明 DLL1 对 BC 细胞具有致癌作用。在 MCF-7、BT474 和 MDA-MB-231 细胞中观察到 DLL1 下调的不同作用可能是由于它们独特的遗传和生物学特征，表明 DLL1 通过多种机制促进 BC 的发生。
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