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佩什门中天然酚类化合物的测定及其抗氧化和抗胆碱酯酶潜力评估。

Determination of natural phenolic compounds of Peşmen and assessment their antioxidant and anticholinesterase potentials.

作者信息

Karakaya Songul, Koca Mehmet, Sytar Oksana, Duman Hayri

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey.

出版信息

Nat Prod Res. 2021 May;35(10):1654-1656. doi: 10.1080/14786419.2019.1619728. Epub 2019 May 29.

Abstract

The paper reports anticholinesterase and antioxidant activities of extracts, fractions from aerial parts, roots, flowers, fruits of Pemen (Apiaceae). Phenolic content, antioxidant activities of samples were carried out using Folin-Ciocalteu, DPPH, TBA methods. Anticholinesterase activity was actualised through Ellman's method. The utmost and least total phenolic content were detected in root MeOH extract (36.4 mg GAE g DW) and aerial part (23.74 mg GAE g DW), respectively. Hexane fraction of root exhibited significant inhibition against AChE (37.99%) and BuChE (81.66%) at 20 μg/mL as well as remarkable antioxidant and anticholinesterase activities. However, investigations on roots will be substantial for improved usage of for pharmaceutical and food search needs.

摘要

该论文报道了伞形科植物佩门地上部分、根、花、果实的提取物和馏分的抗胆碱酯酶及抗氧化活性。采用福林-西奥尔特法、DPPH法、TBA法对样品的酚含量和抗氧化活性进行了测定。抗胆碱酯酶活性通过埃尔曼法实现。根甲醇提取物(36.4毫克没食子酸当量/克干重)和地上部分(23.74毫克没食子酸当量/克干重)中分别检测到最高和最低的总酚含量。根的己烷馏分在20微克/毫升时对乙酰胆碱酯酶(AChE)(37.99%)和丁酰胆碱酯酶(BuChE)(81.66%)表现出显著抑制作用,以及显著的抗氧化和抗胆碱酯酶活性。然而,对根的研究对于满足制药和食品研究需求中佩门的更好利用具有重要意义。

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