Febriyenti Febriyenti, Lucida Henny, Almahdy Almahdy, Alfikriyah Istianah, Hanif Muhammad
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Andalas, Padang 25163, Indonesia.
J Pharm Bioallied Sci. 2019 Apr-Jun;11(2):176-180. doi: 10.4103/jpbs.JPBS_184_18.
Honey has been formulated into gel and film dosage forms for burn wound as previously reported.
In this study, we evaluated the ability of honey gel and film to promote the healing of burns and incision wounds on the skin of Sprague-Dawley female white rats.
Twenty-four female rats were divided into four groups, which were treatment groups (for honey gel or film), negative control, and positive control (treated with marketed product "B"), respectively. Burn and incision wound were created by the method previously reported with slight modification. Parameters such as the percentage of wound closure and the tensile strength of the incision wound were determined.
The experimental results showed that honey film has a greater effectiveness to accelerate the healing for burns and incision wound in comparison to the negative control.
Two-way analysis of variance indicates the type of treatment group, and time has a significant effect on the burn wound ( < 0.05). Honey film shows the significant difference ( < 0.05) with other group on the incision wound.
如先前报道，蜂蜜已被制成凝胶和薄膜剂型用于烧伤创面。
在本研究中，我们评估了蜂蜜凝胶和薄膜促进斯普拉格 - 道利雌性白色大鼠皮肤烧伤和切口伤口愈合的能力。
将24只雌性大鼠分为四组，分别为治疗组（蜂蜜凝胶或薄膜）、阴性对照组和阳性对照组（用市售产品“B”治疗）。采用先前报道的方法并稍作修改制作烧伤和切口伤口。测定伤口闭合百分比和切口伤口抗张强度等参数。
实验结果表明，与阴性对照组相比，蜂蜜薄膜在加速烧伤和切口伤口愈合方面具有更高的有效性。
双向方差分析表明治疗组类型和时间对烧伤创面有显著影响（<0.05）。蜂蜜薄膜在切口伤口方面与其他组有显著差异（<0.05）。
