Wound-Healing Effect of Honey Gel and Film.

BACKGROUND

Honey has been formulated into gel and film dosage forms for burn wound as previously reported.

AIMS

In this study, we evaluated the ability of honey gel and film to promote the healing of burns and incision wounds on the skin of Sprague-Dawley female white rats.

MATERIALS AND METHODS

Twenty-four female rats were divided into four groups, which were treatment groups (for honey gel or film), negative control, and positive control (treated with marketed product "B"), respectively. Burn and incision wound were created by the method previously reported with slight modification. Parameters such as the percentage of wound closure and the tensile strength of the incision wound were determined.

RESULTS

The experimental results showed that honey film has a greater effectiveness to accelerate the healing for burns and incision wound in comparison to the negative control.

CONCLUSIONS

Two-way analysis of variance indicates the type of treatment group, and time has a significant effect on the burn wound ( < 0.05). Honey film shows the significant difference ( < 0.05) with other group on the incision wound.