埃博拉病毒复制突出。
Ebola Virus Replication Stands Out.
机构信息
Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
出版信息
Trends Microbiol. 2019 Jul;27(7):565-566. doi: 10.1016/j.tim.2019.05.004. Epub 2019 May 30.
Abstract
A recent study by Deflubé et al. (Proc. Natl. Acad. Sci. U. S. A. 2019;116:8535-8543) reported that Ebola virus genomes have variable 3' terminal nucleotides. This finding is a departure from other nonsegmented, negative-strand RNA viruses (NNSVs) that have been studied to date and has broad implications for filoviral replication and innate immune evasion.
摘要
德弗吕等人最近的一项研究（Proc. Natl. Acad. Sci. U. S. A. 2019;116:8535-8543）报告称，埃博拉病毒基因组具有可变的 3'末端核苷酸。这一发现与迄今为止研究过的其他非节段性、负链 RNA 病毒（NNSV）不同，对丝状病毒的复制和固有免疫逃避具有广泛的意义。
相似文献
1
Ebola Virus Replication Stands Out.埃博拉病毒复制突出。
Trends Microbiol. 2019 Jul;27(7):565-566. doi: 10.1016/j.tim.2019.05.004. Epub 2019 May 30.
2
Ebolavirus polymerase uses an unconventional genome replication mechanism.埃博拉病毒聚合酶使用一种非常规的基因组复制机制。
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8535-8543. doi: 10.1073/pnas.1815745116. Epub 2019 Apr 8.
3
Modeling Ebola Virus Genome Replication and Transcription with Minigenome Systems.利用微型基因组系统对埃博拉病毒基因组复制和转录进行建模
Methods Mol Biol. 2017;1628:79-92. doi: 10.1007/978-1-4939-7116-9_6.
4
Innate immune evasion by filoviruses.丝状病毒对固有免疫的逃避
Virology. 2015 May;479-480:122-30. doi: 10.1016/j.virol.2015.03.030. Epub 2015 Apr 3.
5
Human transbodies that interfere with the functions of Ebola virus VP35 protein in genome replication and transcription and innate immune antagonism.干扰埃博拉病毒 VP35 蛋白在基因组复制和转录及固有免疫拮抗作用的人体嵌合体。
Emerg Microbes Infect. 2018 Mar 21;7(1):41. doi: 10.1038/s41426-018-0031-3.
6
Mechanisms of Immune Evasion by Ebola Virus.埃博拉病毒的免疫逃逸机制。
Adv Exp Med Biol. 2021;1313:15-22. doi: 10.1007/978-3-030-67452-6_2.
7
Deception through Mimicry: A Cellular Antiviral Strategy.通过模拟进行欺骗：一种细胞抗病毒策略。
Cell. 2018 Dec 13;175(7):1728-1729. doi: 10.1016/j.cell.2018.11.033.
8
An Investigation of the Effect of Transfected Defective, Ebola Virus Genomes on Ebola Replication.转染缺陷型埃博拉病毒基因组对埃博拉病毒复制影响的研究
Front Cell Infect Microbiol. 2020 Apr 21;10:159. doi: 10.3389/fcimb.2020.00159. eCollection 2020.
9
Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery.恢复期男性埃博拉病毒血症患者精液中存在病毒复制和高浓度病毒。
Clin Infect Dis. 2017 Oct 15;65(8):1400-1403. doi: 10.1093/cid/cix518.
10
RNA binding specificity of Ebola virus transcription factor VP30.埃博拉病毒转录因子VP30的RNA结合特异性
RNA Biol. 2016 Sep;13(9):783-98. doi: 10.1080/15476286.2016.1194160. Epub 2016 Jun 17.
本文引用的文献
1
Ebolavirus polymerase uses an unconventional genome replication mechanism.埃博拉病毒聚合酶使用一种非常规的基因组复制机制。
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8535-8543. doi: 10.1073/pnas.1815745116. Epub 2019 Apr 8.
2
Blood kinetics of Ebola virus in survivors and nonsurvivors.埃博拉病毒在幸存者和非幸存者体内的血液动力学
J Clin Invest. 2015 Dec;125(12):4692-8. doi: 10.1172/JCI83111. Epub 2015 Nov 9.
3
Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.丝状病毒发病机制与免疫逃逸：来自埃博拉病毒和马尔堡病毒的见解
Nat Rev Microbiol. 2015 Nov;13(11):663-76. doi: 10.1038/nrmicro3524. Epub 2015 Oct 6.
4
Initiation and regulation of paramyxovirus transcription and replication.副粘病毒转录与复制的起始及调控
Virology. 2015 May;479-480:545-54. doi: 10.1016/j.virol.2015.01.014. Epub 2015 Feb 13.
5
Characterization of a nodavirus replicase revealed a de novo initiation mechanism of RNA synthesis and terminal nucleotidyltransferase activity.一种诺达病毒复制酶的特性揭示了一种新的 RNA 合成起始机制和末端核苷酸转移酶活性。
J Biol Chem. 2013 Oct 25;288(43):30785-801. doi: 10.1074/jbc.M113.492728. Epub 2013 Sep 9.
6
The polymerase of negative-stranded RNA viruses.负链 RNA 病毒的聚合酶。
Curr Opin Virol. 2013 Apr;3(2):103-10. doi: 10.1016/j.coviro.2013.03.008. Epub 2013 Apr 18.
7
Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase.水疱性口炎病毒聚合酶引发 RNA 合成起始的机制。
EMBO J. 2012 Mar 7;31(5):1320-9. doi: 10.1038/emboj.2011.483. Epub 2012 Jan 13.
8
Ebolavirus VP35 is a multifunctional virulence factor.埃博拉病毒 VP35 是一种多功能毒力因子。
Virulence. 2010 Nov-Dec;1(6):526-31. doi: 10.4161/viru.1.6.12984. Epub 2010 Nov 1.
9
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.哺乳动物细胞中区分自身与非自身双链RNA的结构基础。
Nat Biotechnol. 2006 May;24(5):559-65. doi: 10.1038/nbt1205. Epub 2006 Apr 30.
10
Sequence comparison of five polymerases (L proteins) of unsegmented negative-strand RNA viruses: theoretical assignment of functional domains.非节段负链RNA病毒的五种聚合酶（L蛋白）的序列比较：功能结构域的理论定位
J Gen Virol. 1990 May;71 ( Pt 5):1153-62. doi: 10.1099/0022-1317-71-5-1153.
Zotero 插件