Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico.
Laboratory of Biological Anthropology, University of Kansas, Lawrence, KS, USA.
Hum Immunol. 2020 Sep;81(9):544-546. doi: 10.1016/j.humimm.2019.07.282. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1011 Mexicans from the state of Tlaxcala residing in the city of Tlaxcala (N = 181) and rural communities (N = 830), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in Tlaxcala are all of Native American origin. Admixture estimates revealed that the main genetic components are Native American (75.13 ± 1.56% by ML; 69.24% based on of Native American haplotypes) and European (16.10 ± 4.98% by ML; 19.74% of European haplotypes), with a less prominent African genetic component (8.78 ± 4.09% by ML; 4.35% of African haplotypes).
我们通过 PCR-SSP 基于分型的方法在来自塔毛利帕斯州的 1011 名居住在特拉斯卡拉市（N=181）和农村社区（N=830）的墨西哥人中研究了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获得有关等位基因和单倍型频率的信息。我们发现，特拉斯卡拉州最常见的 10 个单倍型均源自美洲原住民。混合估计显示，主要的遗传成分是美洲原住民（ML 估计值为 75.13±1.56%；基于美洲原住民单倍型为 69.24%）和欧洲人（ML 估计值为 16.10±4.98%；基于欧洲人单倍型为 19.74%），而非洲遗传成分则不太突出（ML 估计值为 8.78±4.09%；基于非洲人单倍型为 4.35%）。
