墨西哥普埃布拉两群体 HLA 系统的遗传多样性：普埃布拉市和普埃布拉农村。
Genetic diversity of HLA system in two populations from Puebla, Mexico: Puebla city and rural Puebla.
机构信息
Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):547-549. doi: 10.1016/j.humimm.2019.07.290. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2827 Mexicans from the state of Puebla living in the city of Puebla (N = 1994) and rural communities (N = 833), to obtain information regarding allelic and haplotypic frequencies. We found that the 16 most frequent haplotypes in Puebla are all of them Native American. Admixture estimates revealed that the main genetic components in the state of Puebla are Native American (72.21 ± 1.25% by ML; 63.30% of Native American haplotypes) and European (21.05 ± 1.92% by ML; 23.86% of European haplotypes), and a less prominent African genetic component (6.74 ± 2.20% by ML; 6.20% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法研究了 2827 名来自普埃布拉州的墨西哥人（1994 名居住在普埃布拉市，833 名居住在农村社区）的 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获得有关等位基因和单倍型频率的信息。我们发现，普埃布拉州最常见的 16 个单倍型均为美洲原住民。混合估计显示，普埃布拉州的主要遗传成分是美洲原住民（通过最大似然法计算为 72.21±1.25%；63.30%的美洲原住民单倍型）和欧洲人（通过最大似然法计算为 21.05±1.92%；23.86%的欧洲人单倍型），以及一个不太明显的非洲遗传成分（通过最大似然法计算为 6.74±2.20%；6.20%的非洲人单倍型）。
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