墨西哥克雷塔罗州两个群体的 HLA 系统遗传多样性：克雷塔罗市和农村克雷塔罗。
Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro.
机构信息
HLA Laboratory, Central Blood Bank, Hospital de Especialidades, Unidad Médica de Alta Especialidad (UMAE) Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: http://www.shh.mpg.de/en.
出版信息
Hum Immunol. 2020 Sep;81(9):522-524. doi: 10.1016/j.humimm.2019.07.296. Epub 2019 Jul 25.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42% by ML; 42.61% of Native American haplotypes) and European (48.18 ± 3.55% by ML; 46.02% of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25% by ML; 4.55% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法，对来自墨西哥瓜纳华托州居住在首府克雷塔罗市（45 人）和农村社区（43 人）的 88 名墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因研究，以获取有关等位基因和单倍型频率的信息。我们发现，瓜纳华托州最常见的单倍型包括七个美洲原住民、两个欧洲人和一个亚洲人单倍型。混合估计显示，瓜纳华托州的主要遗传成分是美洲原住民（ML 法 51.82±4.42%；美洲原住民单倍型的 42.61%）和欧洲人（ML 法 48.18±3.55%；欧洲人单倍型的 46.02%），几乎没有非洲遗传成分（ML 法 0.00±4.25%；非洲人单倍型的 4.55%）。
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