墨西哥尤卡坦地区两个群体的 HLA 系统遗传多样性：梅里达和尤卡坦农村。
Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán.
机构信息
Chemistry Faculty, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):569-572. doi: 10.1016/j.humimm.2019.07.280. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Yucatán include 16 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Yucatán are Native American (81.54 ± 4.99% by ML; 62.92% of Native American haplotypes) and European (11.50 ± 15.43% by ML; 23.26% of European haplotypes), and a less prominent African genetic component (6.96 ± 10.47% by ML; 5.93% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法对来自尤卡坦州的 324 名生活在梅里达市（N=192）和农村社区（N=132）的墨西哥人进行了 HLA I 类（HLA-A、-B）和 II 类（HLA-DRB1、-DQB1）等位基因研究，以获取有关等位基因和单倍型频率的信息。我们发现，尤卡坦州最常见的单倍型包括 16 个美洲原住民和 1 个欧洲单倍型。混合估计显示，尤卡坦州的主要遗传成分是美洲原住民（ML 法的 81.54±4.99%；62.92%的美洲原住民单倍型）和欧洲人（ML 法的 11.50±15.43%；23.26%的欧洲人单倍型），以及一个不太突出的非洲遗传成分（ML 法的 6.96±10.47%；5.93%的非洲人单倍型）。
Zotero 插件