Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: http://www.shh.mpg.de/en.
Molecular Immunogenetics Laboratory, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
Hum Immunol. 2020 Sep;81(9):563-565. doi: 10.1016/j.humimm.2019.07.285. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (N = 52) and rural communities (N = 121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61 ± 0.58% by ML; 53.16% of Native American haplotypes) and European (26.39 ± 5.05% by ML; 25.86% of European haplotypes), and a less prominent African genetic component (2.00 ± 5.20% by ML; 9.77% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法研究了来自恰帕斯州的 173 名居住在图斯特拉古铁雷斯市（N=52）和农村社区（N=121）的墨西哥人的 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获得有关等位基因和单倍型频率的信息。我们发现恰帕斯州最常见的单倍型包括 12 种美洲原住民和 1 种欧洲单倍型。混合估计显示，恰帕斯州的主要遗传成分是美洲原住民（通过 ML 为 71.61±0.58%；53.16%的美洲原住民单倍型）和欧洲人（通过 ML 为 26.39±5.05%；25.86%的欧洲人单倍型），以及一个不太明显的非洲遗传成分（通过 ML 为 2.00±5.20%；9.77%的非洲人单倍型）。
