Department of Anesthesiology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Jiangxi Province Key of Laboratory of Anesthesiology, Nanchang, China.
Neurochem Res. 2019 Aug;44(8):1977-1985. doi: 10.1007/s11064-019-02831-3. Epub 2019 Jun 24.
Tripterygium Wilfordii Hook F has been exploited as a treatment for several diseases due to its neuroprotective, anti-tumor, and anti-inflammatory effects. Triptolide is one of its key bioactive compounds. Currently, the role of triptolide in cognitive dysfunction remains unclear. Here, the role of triptolide on cognitive dysfunction was investigated using chronic cerebral hypoperfusion-induced vascular dementia (VD) rat model. SD rats were administrated with Triptolide (5 μg/kg) for 6 weeks after undergoing permanent bilateral common carotid artery occlusion. The results show that triptolide treatment conferred neuroprotective effects in VD rats. Intraperitoneal injection of triptolide attenuated oxidative stress, learning and memory deficits, and neuronal apoptosis in the hippocampi. Moreover, triptolide enhanced the expression of SIRT1, PGC-1α, ZO-1, Claudin-5, and decreased the serum levels of NSE and S100B significantly. It also improved CCH-induced learning and memory deficits, and this is attributed to its capacity to promote SIRT1/PGC-1α signaling, confer antioxidant effects, and inhibit neuronal apoptosis. These findings indicate that triptolide may be an effective therapeutic agent for vascular cognitive dysfunction.
雷公藤红素由于具有神经保护、抗肿瘤和抗炎作用，已被开发用于治疗多种疾病。雷公藤红素是其主要生物活性化合物之一。目前，雷公藤红素在认知功能障碍中的作用尚不清楚。本研究采用慢性大脑低灌注诱导的血管性痴呆（VD）大鼠模型，探讨了雷公藤红素对认知功能障碍的作用。SD 大鼠在永久性双侧颈总动脉闭塞后给予雷公藤红素（5μg/kg）6 周。结果表明，雷公藤红素治疗可减轻 VD 大鼠的神经损伤。腹腔注射雷公藤红素可减轻氧化应激、学习记忆障碍和海马神经元凋亡。此外，雷公藤红素可显著上调 SIRT1、PGC-1α、ZO-1、Claudin-5 的表达，降低血清 NSE 和 S100B 水平。雷公藤红素还可改善 CCH 诱导的学习记忆障碍，这归因于其促进 SIRT1/PGC-1α 信号转导、发挥抗氧化作用和抑制神经元凋亡的能力。这些发现表明，雷公藤红素可能是血管性认知功能障碍的一种有效治疗药物。
