非洲猪瘟病毒亚单位疫苗研究方法
Subunit Vaccine Approaches for African Swine Fever Virus.
作者信息
Gaudreault Natasha N, Richt Juergen A
机构信息
Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, K224 Mosier Hall, 1800 Denison Ave, Manhattan, KS 66506, USA.
出版信息
Vaccines (Basel). 2019 Jun 25;7(2):56. doi: 10.3390/vaccines7020056.
Abstract
African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus region in 2007, a highly virulent, genotype II strain of ASFV has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. This review summarizes various ASFV vaccine strategies that have been investigated, with focus on antigen-, DNA-, and virus vector-based vaccines. Known ASFV antigens and the determinants of protection against ASFV versus immunopathological enhancement of infection and disease are also discussed.
摘要
非洲猪瘟病毒（ASFV）是猪类一种高致死性疾病的病原体，目前尚无可用疫苗。该疾病具有高度传染性，对全球养猪业构成严重威胁。自2007年传入高加索地区以来，一种高致病性的II型ASFV毒株持续传播，扩散至东欧和俄罗斯，最近又蔓延到西欧、中国及东南亚各国。本综述总结了已研究的多种ASFV疫苗策略，重点关注基于抗原、DNA和病毒载体的疫苗。还讨论了已知的ASFV抗原以及针对ASFV的保护性决定因素与感染和疾病免疫病理增强之间的关系。
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