Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Emanuel Institute of Biochemical Physics, RAS, Moscow 119334, Russia.
Molecules. 2019 Jun 26;24(13):2362. doi: 10.3390/molecules24132362.
Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes' active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed.
真菌产生的高度危险的天然化合物叫做真菌毒素。酶转化似乎是脱除真菌毒素最有前途的方法。本文综述了不同类别酶转化各种真菌毒素的最新信息。深入分析了 11 种关键酶机制对几十种主要真菌毒素的作用。此外，还对真菌毒素与酶活性中心的分子对接进行了分析，以阐明其中一些催化机制。通过对来自不同生物体（植物、动物、真菌和细菌）的蛋白质同源物进行分析，讨论了具有高实用潜力的天然活性生物催化剂的普遍性和可用性。还提出了多功能酶组合对真菌毒素解毒的重要性。
