Ali Moustafa R K, Farghali Haithem A M, Wu Yue, El-Sayed Ivan, Osman Ahmed H, Selim Salah A, El-Sayed Mostafa A
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.
Department of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
Cancers (Basel). 2019 Jun 19;11(6):851. doi: 10.3390/cancers11060851.
For localized tumors, gold nanorod (AuNR)-assisted plasmonic photothermal therapy (PPTT) is a potentially effective alternative to traditional surgery, in which AuNRs absorb near-infrared light and convert it to heat in order to kill cancer cells. However, for large tumors (volume ≥ 20 cm), an uneven distribution of AuNRs might cause inhomogeneity of the heat distribution inside the tumor. Surgery is frequently recommended for removing large tumors, but it is associated with a high risk of cancer recurrence and metastasis. Here, we applied PPTT before surgery, which showed improved treatment for large tumors. We divided the animals (eight cats/dogs) into two groups: Group I (control), where three cases were solely treated with surgery, laser, or AuNRs alone, resulting in recurrence and metastasis; and Group II, where animals were treated with PPTT before surgery. In Group II, four out of the five cases had tumor regression without any recurrence or metastasis. Interestingly, we observed that applying PPTT before surgery displayed reduced bleeding during tumor removal, supported by histopathology that showed altered blood vessels. In conclusion, our study showed that applying AuNR-assisted PPTT (AuNRs-PPTT) before surgery could significantly affect blood vessels inside the tumor, leading to a decreased amount of bleeding during surgery, which can potentially decrease the risk of metastasis and blood loss during surgery.
对于局部肿瘤，金纳米棒（AuNR）辅助的等离子体光热疗法（PPTT）是传统手术的一种潜在有效替代方法，其中金纳米棒吸收近红外光并将其转化为热量以杀死癌细胞。然而，对于大肿瘤（体积≥20 cm），金纳米棒分布不均可能导致肿瘤内部热分布不均匀。手术通常被推荐用于切除大肿瘤，但它与癌症复发和转移的高风险相关。在此，我们在手术前应用PPTT，结果显示对大肿瘤的治疗效果有所改善。我们将动物（8只猫/狗）分为两组：第一组（对照组），其中3例仅接受手术、激光或单独的金纳米棒治疗，结果出现复发和转移；第二组，动物在手术前接受PPTT治疗。在第二组中，5例中有4例肿瘤消退，无任何复发或转移。有趣的是，我们观察到在手术前应用PPTT可减少肿瘤切除过程中的出血，组织病理学支持这一点，其显示血管发生了改变。总之，我们的研究表明，在手术前应用金纳米棒辅助的PPTT（AuNRs-PPTT）可显著影响肿瘤内部的血管，导致手术期间出血量减少，这可能潜在地降低手术期间转移和失血的风险。
