Messenguy F, Dubois E
Research Institute of the CERIA, Brussels, Belgium.
Mol Gen Genet. 1988 Jan;211(1):102-5. doi: 10.1007/BF00338399.
Three regulatory proteins are involved in the post-transcriptional control of arginine metabolism in Saccharomyces cerevisiae: ARGRI, ARGRII and ARGRIII. The 880 amino acid ARGRII protein, like some DNA binding proteins, possesses in its N-terminal sequence a cysteine-rich region that presents homology to the zinc binding region of Escherichia coli aspartate transcarbamylase. ARGRII also has a region of 90 amino acids that is 30% homologous to the E. coli ARGR repressor. Moreover a 87 amino acid long sequence of ARGRII contains three stretches with significant homology to some viral, bacterial and pancreatic RNases. We propose a model in which the RNase-like sequence could regulate the expression of arginine anabolic messenger RNAs.
ARGRI、ARGRII和ARGRIII。880个氨基酸的ARGRII蛋白，与一些DNA结合蛋白类似，在其N端序列中拥有一个富含半胱氨酸的区域，该区域与大肠杆菌天冬氨酸转氨甲酰酶的锌结合区域具有同源性。ARGRII还有一个90个氨基酸的区域，与大肠杆菌ARGR阻遏物有30%的同源性。此外，ARGRII的一段87个氨基酸长的序列包含三个与一些病毒、细菌和胰腺核糖核酸酶有显著同源性的片段。我们提出了一个模型，其中类似核糖核酸酶的序列可能调节精氨酸合成信使核糖核酸的表达。
