Université de Lille, Inserm, CHU Lille, UMR-S 1172, Laboratoire du Développement et Plasticité du Cerveau Neuroendocrine, Centre de Recherche Jean-Pierre Aubert, Lille, France.
Institut de Biologie de la Reproduction-Spermiologie-CECOS, CHU de Lille, Lille, France.
Neuroendocrinology. 2019;109(3):218-229. doi: 10.1159/000500689. Epub 2019 Jul 5.
Since its initial discovery in the 1940s, research into the physiological actions of anti-Müllerian hormone (AMH), from its eponymous role in male developmental biology to its routine clinical use in female reproductive health, has undergone a paradigm shifting change. With several exciting studies recently reporting hitherto unforeseen AMH actions at all levels in the hypogonadal-pituitary-gonadal axis, the importance of this hormone for both hypothalamic and pituitary reproductive control is finding increasing support and significance. In this review, we will briefly summarize what is known about the traditional roles and biology of AMH and how this could be integrated with new findings of AMH actions at the level of the hypothalamic-pituitary axis. We also synthesize the important findings from these new studies and discuss their potential impact and significance to our understanding of one of the most common reproductive disorders currently affecting women, polycystic ovary syndrome.
自 20 世纪 40 年代首次发现抗苗勒管激素 (AMH) 以来，其在男性发育生物学中的命名作用及其在女性生殖健康中的常规临床应用的研究已经发生了范式转变。最近有几项令人兴奋的研究报告称，在性腺轴的所有水平上，AMH 都有以前未曾预料到的作用，这使得该激素对于下丘脑和垂体的生殖控制的重要性得到了越来越多的支持和重视。在这篇综述中，我们将简要总结 AMH 的传统作用和生物学特性，以及如何将其与 AMH 在下丘脑-垂体轴水平上的新发现相结合。我们还综合了这些新研究的重要发现，并讨论了它们对我们理解目前影响女性最常见的生殖障碍之一——多囊卵巢综合征的潜在影响和意义。
