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基于社区的高血压筛查对两年后血压的影响:中国老年人群全国队列的回归间断分析。

Impact of community based screening for hypertension on blood pressure after two years: regression discontinuity analysis in a national cohort of older adults in China.

机构信息

Heidelberg Institute of Global Health, Faculty of Medicine and University Hospital, Heidelberg University, 69120 Heidelberg, Germany

Heidelberg Institute of Global Health, Faculty of Medicine and University Hospital, Heidelberg University, 69120 Heidelberg, Germany.

出版信息

BMJ. 2019 Jul 11;366:l4064. doi: 10.1136/bmj.l4064.

Abstract

OBJECTIVE

To estimate the causal impact of community based blood pressure screening on subsequent blood pressure levels among older adults in China.

DESIGN

Regression discontinuity analysis using data from a national cohort study.

SETTING

2011-12 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey, a national cohort of older adults in China.

PARTICIPANTS

3899 older adults who had previously undiagnosed hypertension.

INTERVENTION

Community based hypertension screening among older adults in 2011-12.

MAIN OUTCOME MEASURE

Blood pressure two years after initial screening.

RESULTS

The intervention reduced systolic blood pressure: -6.3 mm Hg in the model without covariates (95% confidence interval -11.2 to -1.3) and -8.3 mm Hg (-13.6 to -3.1) in the model that adjusts additionally for demographic, social, and behavioural covariates. The impact on diastolic blood pressure was smaller and non-significant in all models. The results were similar when alternative functional forms were used to estimate the impact and the bandwidths around the intervention threshold were changed. The results did not vary by demographic and social subgroups.

CONCLUSIONS

Community based hypertension screening and encouraging people with raised blood pressure to seek care and adopt blood pressure lowering behaviour changes could have important long term impact on systolic blood pressure at the population level. This approach could address the high burden of cardiovascular diseases in China and other countries with large unmet need for hypertension diagnosis and care.

摘要

目的

评估社区为基础的血压筛查对中国老年人后续血压水平的因果影响。

设计

使用来自全国队列研究的数据进行回归不连续性分析。

地点

中国纵向健康长寿调查的 2011-12 年和 2014 年波次,这是一个中国老年人群体的全国队列。

参与者

3899 名此前未被诊断为高血压的老年人。

干预

2011-12 年对老年人进行社区高血压筛查。

主要观察指标

初次筛查后两年的血压。

结果

干预降低了收缩压:在无协变量的模型中为-6.3mmHg(95%置信区间为-11.2 至-1.3),在另外调整了人口统计学、社会和行为协变量的模型中为-8.3mmHg(-13.6 至-3.1)。在所有模型中,对舒张压的影响较小且无统计学意义。当使用替代功能形式来估计影响以及改变干预阈值周围的带宽时,结果相似。结果在人口统计学和社会亚组之间没有差异。

结论

社区为基础的高血压筛查以及鼓励血压升高的人寻求医疗并采取降低血压的行为改变,可能会对人群的收缩压产生重要的长期影响。这种方法可以解决中国以及其他国家心血管疾病负担高的问题,这些国家对高血压的诊断和治疗存在巨大的未满足需求。

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