Department of Dermatology, Faculty of Medicine, Başkent University Adana Hospital, Adana, Turkey.
Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.
Mycopathologia. 2020 Feb;185(1):187-192. doi: 10.1007/s11046-019-00358-3. Epub 2019 Jul 11.
Dermatophytic granuloma characterized by perifollicular granulomatous inflammation was first described by Domenico Majocchi and was later named after him, Majocchi's granuloma (MG). Although the initial description was related to a dermatophyte Trichophyton tonsurans, later reports linked MG to non-dermatophytes (Phoma, Aspergillus, Malbranchea), which led to a confusion of disease patterns caused by cutaneous pathogens and general opportunistic microorganisms. Furthermore, several causative agents of MG described in the literature were not confirmed as such. Our review addressed the following aspects: (1) significance of histopathological finding for MG diagnosis, (2) dermatophytes as exclusive agents of MG, (3) spectrum of etiological agents causing different types of invasive dermatophytic infections, and (4) treatment options.
以毛囊为中心的肉芽肿性炎症为特征的真菌性肉芽肿首先由多梅尼科·马乔基（Domenico Majocchi）描述，并以他的名字命名，即马乔基氏肉芽肿（MG）。虽然最初的描述与亲动物性皮肤癣菌须癣毛癣菌有关，但后来的报道将 MG 与非亲动物性皮肤癣菌（青霉、曲霉、Malbranchea）联系起来，这导致了由皮肤病原体和一般机会性微生物引起的疾病模式的混淆。此外，文献中描述的 MG 的几个致病因子也未被确认为 MG。我们的综述涉及以下几个方面：（1）组织病理学发现对 MG 诊断的意义，（2）亲动物性皮肤癣菌作为 MG 的唯一致病因子，（3）引起不同类型侵袭性皮肤癣菌感染的病因谱，以及（4）治疗选择。
