Khodadadi Ryan B, Yetmar Zachary A, Montagnon Carmen M, Johnson Emma F, Abu Saleh Omar M
Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota.
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
JAAD Int. 2023 Aug 23;13:104-111. doi: 10.1016/j.jdin.2023.08.010. eCollection 2023 Dec.
Majocchi's granuloma (MG) is an uncommon deep fungal folliculitis predominantly caused by dermatophytes. Given the rarity of this condition, available data regarding predisposing comorbidities/risk factors, clinical characteristics, offending microbiologic pathogens, diagnostics, pathologic findings, and treatment approaches has been inferred from historical cases.
To review our institutional experience with MG.
We retrospectively analyzed a multicenter cohort of adult patients diagnosed with MG between 1992 and 2022.
We analyzed 147 patients with MG, 105 of which were male with a median age of 55.6 years. Immunosuppressant and topical corticosteroid use were common prior to development of MG. Dermatologic lesions and their sites of involvement did not differ based on the immune status of patients. was the most common causative pathogen of MG, in addition to other dermatophytes. Treatment duration for all prescribed agents was median 31.5 days with oral terbinafine being the most frequently utilized agent. Clinical resolution was achieved in 96.6% of cases.
Retrospective, nonrandomized study.
Although rare and clinically variable in presentation, diagnosis of MG often requires histopathologic confirmation to subsequently direct prolonged treatment with systemic antifungal therapy for mycological cure.
Majocchi 肉芽肿（MG）是一种罕见的深部真菌性毛囊炎，主要由皮肤癣菌引起。鉴于这种疾病的罕见性，有关易感合并症/危险因素、临床特征、致病微生物病原体、诊断、病理结果和治疗方法的现有数据是从历史病例中推断出来的。
回顾我们机构对 MG 的治疗经验。
我们回顾性分析了 1992 年至 2022 年间诊断为 MG 的成年患者的多中心队列。
我们分析了 147 例 MG 患者，其中 105 例为男性，中位年龄为 55.6 岁。在 MG 发病之前，免疫抑制剂和外用糖皮质激素的使用很常见。皮肤病变及其受累部位不因患者的免疫状态而异。除其他皮肤癣菌外， 是 MG 最常见的致病病原体。所有处方药物的治疗持续时间中位数为 31.5 天，口服特比萘芬是最常用的药物。96.6% 的病例实现了临床缓解。
回顾性、非随机研究。
尽管 MG 罕见且临床表现多变，但诊断通常需要组织病理学确认，随后指导进行长期全身抗真菌治疗以实现真菌学治愈。
