Veerakumar Renuka Devi, Murthy Aravind Baskar, Cinna T Durai Priya, Narasimhan Murali
Dermatology, Venereology, and Leprosy, Sri Ramaswamy Memorial (SRM) Medical College Hospital and Research Centre, Chennai, IND.
Cureus. 2024 Oct 18;16(10):e71807. doi: 10.7759/cureus.71807. eCollection 2024 Oct.
Majocchi's granuloma represents a unique dermatological entity characterized by the invasion of dermatophytes into the dermis and subcutaneous tissue, typically following trauma or topical corticosteroids, most commonly caused by . The unrestrained use of over-the-counter topical steroids has led to the rise of Majocchi's granuloma in the past few years. A 57-year-old male presented with complaints of itchy skin lesions over his right ankle for 20 days. There was a history of over-the-counter topical steroid application, following which the lesions exacerbated. Clinical examination showed multiple ill-defined erythematous nodules, 2-3 cm in size, with serosanguinous discharge associated with right ankle swelling. A single annular hyperpigmented scaly patch was also noted over the right leg below the knee. Potassium hydroxide (KOH) examination was positive for fungal hyphae. Histopathological examination (HPE) of the nodule showed features suggestive of Majocchi's granuloma. Fungal culture was performed, which showed growth of . The patient was started on oral terbinafine 250 mg once daily and topical luliconazole cream twice daily topical application, which resolved the lesions in three weeks, but the patient was advised to continue the treatment for a total duration of two months.
Majocchi 肉芽肿是一种独特的皮肤病实体，其特征是皮肤癣菌侵入真皮和皮下组织，通常继发于创伤或外用糖皮质激素之后，最常见的病因是 。在过去几年中，非处方外用类固醇的无节制使用导致了 Majocchi 肉芽肿的增多。一名 57 岁男性因右踝部皮肤瘙痒性病变 20 天前来就诊。有使用非处方外用类固醇的病史，之后病变加重。临床检查发现多个边界不清的红斑结节，大小为 2 - 3 厘米，伴有血性浆液性渗出，右踝肿胀。右膝以下小腿还可见一个单一的环状色素沉着鳞屑斑。氢氧化钾（KOH）检查真菌菌丝阳性。结节的组织病理学检查（HPE）显示有 Majocchi 肉芽肿的特征。进行了真菌培养，结果显示 生长。患者开始口服特比萘芬 250 毫克，每日一次，外用卢立康唑乳膏，每日两次，三周后病变消退，但建议患者继续治疗两个月。
