比较 2 型糖尿病伴种植体周围炎和无糖尿病种植体周围炎患者龈下口腔生物膜中酵母物种的差异。
Comparison of yeast species in the subgingival oral biofilm of individuals with type 2 diabetes and peri-implantitis and individuals with peri-implantitis without diabetes.
机构信息
Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Clinical Dental Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
出版信息
J Periodontol. 2019 Dec;90(12):1383-1389. doi: 10.1002/JPER.19-0091. Epub 2019 Sep 11.
BACKGROUND
There are no studies that have investigated the presence of yeasts in the subgingival oral biofilm (OB) of type-2 diabetic and non-diabetic patients with peri-implantitis. The aim was to assess the presence of yeasts in the subgingival OB of patients with type 2 diabetes and peri-implantitis and patients with peri-implantitis without diabetes.
METHODS
Patients with type 2 diabetes with peri-implantitis (group A), non-diabetic individuals with peri-implantitis and without diabetes (group B), and individuals with and without peri-implantitis (group C) were included. Lifestyle-related and demographic data were collected using a questionnaire and hemoglobin A1c levels were measured. Peri-implant plaque index (PI), bleeding on probing (BOP), and probing depth (PD) were evaluated and crestal bone loss (CBL) were measured. Subgingival OB samples were collected and oral yeasts species were identified using ChromAgar medium. Level of significance was set at P <0.05.
RESULTS
The mean age of individuals in groups A (n = 43), B (n = 41), and C (n = 42) were 55.6 ± 6.4, 54.6 ± 4.5, and 57.1 ± 3.3 years, respectively. The mean HbA1c levels were higher in group A (P <0.01) than groups B and C. Peri-implant PI (P <0.01), BOP (P <0.01), PD (P <0.01), and CBL (P <0.01) were significantly higher in group A compared with patients in groups B and C. Peri-implant PI (P <0.05), BOP (P <0.05), PD (P <0.05), and CBL (P <0.05) were significantly higher among patients in group B compared with group C. Subgingival yeasts were more often isolated from the OB of patients in groups A (74.4%) and B (46.3%) than group C (7.1%). The most common yeast species identified in all groups was Candida albicans. The CFU/mL for subgingival yeasts were higher in group A than groups B (P <0.01) and C (P <0.01). The CFU/mL for subgingival yeasts were higher in group B than group C (P <0.01).
CONCLUSION
Candida species (predominantly C. albicans) were more often present in the subgingival OB of patients with and without type 2 diabetes with peri-implantitis than systemically healthy individuals without peri-implant diseases.
背景
目前尚无研究调查过 2 型糖尿病和非糖尿病牙周炎患者的龈下口腔生物膜（OB）中是否存在酵母菌。本研究旨在评估 2 型糖尿病伴牙周炎患者（A 组）、非糖尿病牙周炎患者（B 组）和无牙周炎及无糖尿病患者（C 组）的龈下 OB 中酵母菌的存在情况。采用问卷收集与生活方式相关的人口统计学数据，并测量糖化血红蛋白（HbA1c）水平。评估牙周探诊菌斑指数（PI）、探诊出血（BOP）和探诊深度（PD），测量牙槽骨嵴顶吸收（CBL）。采集龈下 OB 样本，采用 ChromAgar 培养基鉴定口腔酵母菌种类。设显著性水平为 P<0.05。
结果
A 组（n=43）、B 组（n=41）和 C 组（n=42）患者的平均年龄分别为 55.6±6.4、54.6±4.5 和 57.1±3.3 岁。A 组的平均 HbA1c 水平显著高于 B 组和 C 组（P<0.01）。与 B 组和 C 组患者相比，A 组的牙周探诊 PI（P<0.01）、BOP（P<0.01）、PD（P<0.01）和 CBL（P<0.01）显著更高。与 C 组患者相比，B 组患者的牙周探诊 PI（P<0.05）、BOP（P<0.05）、PD（P<0.05）和 CBL（P<0.05）也显著更高。与 C 组患者相比，A 组和 B 组患者龈下 OB 中更常分离出酵母菌（A 组 74.4%，B 组 46.3%）。在所有组中，最常见的酵母菌是白色念珠菌。与 B 组和 C 组相比，A 组龈下酵母菌的 CFU/mL 更高（P<0.01）。与 C 组相比，B 组龈下酵母菌的 CFU/mL 更高（P<0.01）。
结论
与系统健康的无牙周疾病患者相比，2 型糖尿病伴牙周炎和非糖尿病牙周炎患者的龈下 OB 中更常存在酵母菌（主要为白色念珠菌）。
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