Department of Psychiatry, University of California, San Francisco, California.
Department of Psychiatry & Behavioral Neuroscience, The University of Chicago (Emeritus), Chicago, Illinois.
Int J Eat Disord. 2019 Sep;52(9):996-1003. doi: 10.1002/eat.23138. Epub 2019 Jul 18.
The evolution toward more stringent conceptualizations of remission in family therapy for adolescent anorexia nervosa (AN) has, with time, introduced variability in outcomes across randomized controlled trials (RCTs). An examination of remission across the history of research on family therapy for AN shows that earlier studies adopted lenient definitions and generally yielded higher rates of remission than studies of the past decade that have used stricter definitions of remission. In this study, we investigate the reactivity of remission rates to the application of different definitions of remission used within the family therapy for AN literature, within a single RCT data set.
We conducted a secondary analysis of data from a single-site RCT which compared the relative efficacy of two formats of family therapy in a sample of 106 Australian adolescents with AN. Using end-of-treatment data, we compared remission rates using 11 definitions of remission that have been used in studies of family therapy for AN spanning more than three decades.
We found wide variability in remission rates (21.7-87.7%; Cochran's Q χ (10, N = 106) = 303.55, p = .000], depending on which definition of remission was applied. As expected, more lenient criteria produced higher remission rates than more stringent definitions.
Applying different criteria of remission to a single data set illustrates the impact of changing how remission is defined. Failure to consider the greater stringency of remission criteria in recent studies could result in false inferences concerning the efficacy of family therapy for AN over time.
随着时间的推移,青少年厌食症(AN)家庭治疗中对缓解的概念越来越严格,这导致了随机对照试验(RCT)的结果出现了变化。对 AN 家庭治疗研究历史上的缓解情况进行检查表明,早期研究采用了宽松的定义,并且通常比过去十年使用更严格的缓解定义的研究产生更高的缓解率。在这项研究中,我们在单个 RCT 数据集内研究了不同的缓解定义对缓解率的反应性。
我们对一项单站点 RCT 的数据进行了二次分析,该 RCT 比较了两种家庭治疗格式在 106 名澳大利亚 AN 青少年样本中的相对疗效。使用治疗结束时的数据,我们使用了 11 种在超过 30 年的 AN 家庭治疗研究中使用的缓解定义来比较缓解率。
我们发现缓解率差异很大(21.7-87.7%;Cochran's Q χ (10, N = 106) = 303.55, p =.000],这取决于应用的缓解定义。正如预期的那样,更宽松的标准比更严格的定义产生更高的缓解率。
将不同的缓解标准应用于单个数据集说明了改变缓解定义的影响。如果不考虑最近研究中缓解标准的更大严格性,可能会导致对 AN 家庭治疗随时间推移的疗效产生错误推断。