Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada.
Nutrients. 2019 Jul 17;11(7):1624. doi: 10.3390/nu11071624.
Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to develop over many years, making it difficult to identify until much later when kidney function is severely impaired and undergoing kidney failure. Although conservative care, symptom management, medication, dialysis, transplantation, and aggressive renal cancer therapy are some of the current strategies/approaches to kidney disease treatment, new preventative targeted therapies are needed. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with health benefits including protection against kidney disease and renal cancer. Resveratrol, a polyphenol found in grapes and berries, has been reported to have antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, and anti-cancer properties. The current review summarizes the existing in vitro and in vivo animal and human studies examining the nephroprotective effects of resveratrol.
影响肾脏的不同疾病和紊乱包括但不限于肾小球肾炎、糖尿病肾病、多囊肾病、肾结石、肾纤维化、脓毒症和肾细胞癌。肾脏疾病往往需要多年的时间才能发展，因此很难在肾脏功能严重受损并出现肾衰竭之前发现。尽管保守治疗、症状管理、药物治疗、透析、移植和积极的肾癌治疗是目前治疗肾脏疾病的一些策略/方法，但仍需要新的预防性靶向治疗。流行病学研究表明，富含水果和蔬菜的饮食与健康益处相关，包括预防肾脏疾病和肾癌。白藜芦醇是葡萄和浆果中发现的一种多酚，已被报道具有抗氧化、抗炎、抗糖尿病、保肝、神经保护和抗癌特性。目前的综述总结了现有的体外和体内动物和人体研究，这些研究检查了白藜芦醇的肾脏保护作用。
