Murray B E, An F Y, Clewell D B
Department of Medicine, University of Texas Medical School, Houston 77030.
Antimicrob Agents Chemother. 1988 Apr;32(4):547-51. doi: 10.1128/AAC.32.4.547.
Streptococcus (Enterococcus) faecalis HH22 is a clinical isolate that produces beta-lactamase and is resistant to various other antimicrobial agents. In this study, HH22 was found to contain three conjugative plasmids and a conjugative transposon. pBEM10 encodes beta-lactamase, gentamicin resistance, and a response to the peptide pheromone cAD1; pAM323 encodes erythromycin resistance; and pAM324 encodes no known resistance. The latter two plasmids respond to pheromones designated cAM323 and cAM324 which are unrelated to other previously characterized pheromones. pBEM10 and pAM323 are the second and third examples of naturally occurring R plasmids that confer a sex pheromone response.
粪肠球菌HH22是一种临床分离株，可产生β-内酰胺酶并对多种其他抗菌剂耐药。在本研究中，发现HH22含有三种接合质粒和一个接合转座子。pBEM10编码β-内酰胺酶、庆大霉素抗性以及对肽信息素cAD1的反应；pAM323编码红霉素抗性；pAM324不编码已知抗性。后两种质粒对命名为cAM323和cAM324的信息素产生反应，这些信息素与其他先前鉴定的信息素无关。pBEM10和pAM323是赋予性信息素反应的天然存在的R质粒的第二个和第三个实例。
