大鼠中黑质纹状体和中脑边缘系统对睡眠-觉醒行为的控制。
Nigrostriatal and mesolimbic control of sleep-wake behavior in rat.
机构信息
Department of Neurobiology, Institute for Basic Research on Aging and Medicine, and Department of Pharmacology, School of Basic Medical Science, Shanghai Medical College, Fudan University, Rm 115, Building 7, 138 YiXueYuan Rd, Shanghai, 200032, China.
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 709 CLS, Blackfan Circle #3, Boston, MA, 02115, USA.
出版信息
Brain Struct Funct. 2019 Sep;224(7):2525-2535. doi: 10.1007/s00429-019-01921-w. Epub 2019 Jul 19.
Abstract
The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.
摘要
中脑多巴胺系统通过背侧纹状体和腹侧纹状体调节广泛的行为。为了解析多巴胺能投射到背侧纹状体（黑质纹状体投射）和腹侧纹状体（中脑边缘投射）在睡眠-觉醒行为中的作用，我们选择性地化学刺激黑质纹状体或中脑边缘投射，并观察它们对大鼠睡眠的影响。刺激黑质纹状体通路增加了睡眠和 EEG 德尔塔功率，而刺激中脑边缘通路则减少了睡眠并降低了皮质 EEG 功率。这些结果表明，背侧或腹侧纹状体中的中脑多巴胺信号分别促进睡眠或觉醒。
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