Oguntibeju Oluwafemi O
Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, 7535, South Africa.
Vet World. 2019 May;12(5):653-663. doi: 10.14202/vetworld.2019.653-663. Epub 2019 May 11.
Wounds have a serious negative impact on the health-care economy of a country, especially on the economy of developing countries where resources are poor and funding is very limited. It is presumed that about 80% of people living in developing countries use traditional medicines which are majorly prepared from medicinal plants to meet their primary health-care needs. Due to the large reservoir of medicinal plants and adequate traditional knowledge on wound healing, many people in Africa and other developing countries use medicinal plants in the treatment of diabetic wounds and related complications. Wound healing in the external and internal biological organs involves a series of complex overlapping processes which demand excellent communication between cells. It is an orderly and highly controlled process characterized by hemostasis, inflammation, proliferation, and remodeling. Diabetes is a global health problem predicted to rise to over 642 million by 2040. The propelling factor responsible for the increase in morbidity and mortality of diabetes is linked to vascular complications as well as the failure of the wound healing processes in diabetic state. Different approaches have been adopted in the treatment of diabetic wounds, and medicinal plants are certainly one of those approaches that have drawn global attention. In this review paper, the effects of medical plants on wound healing in diabetic state as well as factors affecting wound healing and the mechanism of action of medicinal plants are examined.
伤口对一个国家的医疗保健经济有严重的负面影响，尤其是对资源匮乏、资金非常有限的发展中国家的经济。据推测，生活在发展中国家的约80%的人使用主要由药用植物制成的传统药物来满足其基本医疗保健需求。由于药用植物资源丰富以及在伤口愈合方面有足够的传统知识，非洲和其他发展中国家的许多人使用药用植物治疗糖尿病伤口及相关并发症。体内外生物器官的伤口愈合涉及一系列复杂的重叠过程，这需要细胞之间进行良好的沟通。它是一个有序且高度受控的过程，其特征为止血、炎症、增殖和重塑。糖尿病是一个全球性的健康问题，预计到2040年将增至6.42亿以上。导致糖尿病发病率和死亡率上升的推动因素与血管并发症以及糖尿病状态下伤口愈合过程的失败有关。糖尿病伤口的治疗采用了不同的方法，药用植物无疑是引起全球关注的方法之一。在这篇综述文章中，研究了药用植物对糖尿病状态下伤口愈合的影响、影响伤口愈合的因素以及药用植物的作用机制。
