Torres-Martinez Erick José, Cornejo Bravo José Manuel, Serrano Medina Aracely, Pérez González Graciela Lizeth, Villarreal Gómez Luis Jesús
Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390, Mexico.
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Unidad Otay, Tijuana, Baja California, México.
Curr Drug Deliv. 2018;15(10):1360-1374. doi: 10.2174/1567201815666180723114326.
Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application. The high surface-to-volume ratio of the fibers can improve some processes, such as cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the controlled release of active substances ranging from antibiotics and anticancer agents to macromolecules such as proteins and DNA. The advantage of this method is that a wide variety of low solubility drugs can be loaded into the fibers to improve their bioavailability or to attain controlled release. This review presents an overview of the reported drugs loaded into polymeric nanofibers, to be used as drug delivery systems. For instance, it presents the reports on drugs with different bioactivities such as antiinflammatory, anti-microbial, anticancer, cardiovascular, anti-histamine, gastrointestinal, palliative and contraceptive drugs, etc. It also analyzes the electrospinning techniques used in each system, as well as the polymers used as matrices for the preparation of the nanofibers; unfolding the advantages of electrospun polymeric nanofibers over other drug delivery systems. This review intends to enlist and summarize the reported literature concerning this topic. In addition, it proposes future research in the field.
最近，电纺聚合物纳米纤维已被证明是药物递送系统应用的一种有趣策略。纤维的高比表面积可以改善一些过程，如细胞结合与增殖、药物负载和传质过程。静电纺丝最重要且研究最多的领域之一是药物递送领域，用于从抗生素、抗癌剂到蛋白质和DNA等大分子活性物质的控释。该方法的优点是可以将多种低溶解度药物负载到纤维中，以提高其生物利用度或实现控释。本综述概述了已报道的负载于聚合物纳米纤维中用作药物递送系统的药物。例如，它介绍了具有不同生物活性的药物的报道，如抗炎药、抗菌药、抗癌药、心血管药物、抗组胺药、胃肠道药物、姑息治疗药物和避孕药等。它还分析了每个系统中使用的静电纺丝技术，以及用作制备纳米纤维基质的聚合物；展现了电纺聚合物纳米纤维相对于其他药物递送系统的优势。本综述旨在列举并总结有关该主题的已报道文献。此外，它还提出了该领域未来的研究方向。
