School of Public Health, Lanzhou University, Lanzhou, 730000, PR China; Evidence-based Social Science Research Center, Lanzhou University, Lanzhou, 730000, PR China; Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, PR China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, PR China.
Clinical Medical College, Traditional Chinese Medicine of Gansu Province, Lanzhou, 730000, PR China.
Complement Ther Med. 2019 Aug;45:114-123. doi: 10.1016/j.ctim.2019.06.002. Epub 2019 Jun 5.
To summarize the evidence from systematic reviews (SRs) and meta-analyses that evaluated the efficacy of ginger in treating any conditions and critically assess the quality of these evidence.
A systematic search of the literature was conducted from inception until February 28, 2019 using the PubMed, EMBASE, Web of science, Cochrane library, and four Chinese databases. Literature selection and data extraction were conducted by two independent reviewers. The quality of SRs was evaluated using the AMSTAR-2 tool. The GRADE system was used to assess the quality of evidence.
Twenty-seven SRs were included. The number of included studies were various, range from 3 to 27. The condition with the most included SRs was nausea and vomiting (n = 12, 44.4%). Many SRs showed a promising efficacy of ginger, including nausea and vomiting, metabolic syndrome and pain, while the effect of ginger for platelet aggregation failed to draw a certain conclusion. The quality of SRs was heterogeneous. All of included SRs well complied with the Item 1 ("research questions included the components of PICO") and Item 3 ("explained selection of the study designs for inclusion"). Twenty review failed to provide registration information. Only one SR reported the sources of funding for studies included.
In our overview, most of SRs suggest ginger is a promising herbal medicine for health care, which is beneficial for nausea and vomiting, metabolic syndrome and pain. However, considering the limited quality of included evidence and heterogeneity of different clinical trials, more well-design studies are required to confirm the conclusion further.
总结系统评价（SRs）和荟萃分析评估生姜治疗任何疾病疗效的证据，并对这些证据的质量进行批判性评估。
从建库起至 2019 年 2 月 28 日，我们对 PubMed、EMBASE、Web of science、Cochrane 图书馆和四个中文数据库进行了系统检索。文献选择和数据提取由两名独立的评审员进行。使用 AMSTAR-2 工具评估 SRs 的质量。使用 GRADE 系统评估证据质量。
共纳入 27 项 SR。纳入研究的数量各不相同，范围从 3 到 27。纳入 SR 最多的疾病是恶心和呕吐（n=12，44.4%）。许多 SR 表明生姜具有令人鼓舞的疗效，包括恶心和呕吐、代谢综合征和疼痛，而生姜对血小板聚集的影响则未能得出明确结论。SR 的质量存在异质性。所有纳入的 SR 均很好地符合了项目 1（“研究问题包括 PICO 的组成部分”）和项目 3（“解释纳入研究设计的选择”）。20 篇综述未能提供注册信息。只有 1 篇 SR 报告了纳入研究的资金来源。
在我们的综述中，大多数 SR 表明生姜是一种有前途的草药，有益于健康，对恶心和呕吐、代谢综合征和疼痛有益。然而，考虑到纳入证据的质量有限和不同临床试验的异质性，需要更多设计良好的研究来进一步证实这一结论。
