Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland.
BMC Cancer. 2019 Jul 23;19(1):727. doi: 10.1186/s12885-019-5952-2.
Prognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities.
Gene expression data was analyzed from three independent colon cancer microarray gene expression data sets (N = 1052). Survival analysis was performed for the three data sets, stratified by the expression level of the LINE-1 type transposase domain containing 1 (L1TD1). Correlation analysis was performed to investigate the role of the interactome of L1TD1 in colon cancer patients.
We found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with longer disease-free survival in all the three data sets. Our results were in contrast to a previous study on medulloblastoma, where high expression of L1TD1 was linked with poor prognosis. Notably, in medulloblastoma L1TD1 was co-expressed with its interaction partners, whereas our analysis revealed lack of co-expression of L1TD1 with its interaction partners in colon cancer.
Our results identify increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients.
针对特定癌症类型的预后标志物有助于评估患者的生存概率，并帮助临床医生评估可用的治疗方式。
对三个独立的结肠癌微阵列基因表达数据集（N=1052）进行了基因表达数据分析。对三个数据集进行了生存分析，按 LINE-1 型转座酶结构域包含 1（L1TD1）的表达水平进行分层。进行了相关性分析，以研究 L1TD1 的相互作用组在结肠癌患者中的作用。
我们发现 L1TD1 是结肠癌的一个新的阳性预后标志物。在所有三个数据集，L1TD1 的高表达与无病生存期延长相关。我们的结果与先前关于成神经管细胞瘤的研究相反，在成神经管细胞瘤中，L1TD1 的高表达与预后不良相关。值得注意的是，在成神经管细胞瘤中，L1TD1 与其相互作用伙伴共表达，而我们的分析显示，在结肠癌中 L1TD1 与其相互作用伙伴缺乏共表达。
我们的结果表明，L1TD1 的高表达可作为预测结肠癌患者无病生存期延长的预后标志物。
