Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
J Antibiot (Tokyo). 2019 Nov;72(11):843-847. doi: 10.1038/s41429-019-0214-8. Epub 2019 Jul 23.
Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC = 9.9 µM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 µM for each compound). Compound 1 was inactivity in both cytotoxic and anti-microbial assays.
从麒麟菜内生真菌米根霉中分离得到三个新的二苯并螺环缩酮化合物aspermicrones A-C（1-3）。通过高分辨电喷雾电离质谱和核磁共振波谱数据分析确定了它们的化学结构。通过实验和 TD-DFT 理论计算圆二色谱确定了它们的绝对构型。化合物 2 对 HepG2 细胞系表现出选择性细胞毒性（IC = 9.9 μM）。此外，化合物 2 和 3 对金黄色葡萄球菌均表现出抗菌活性（每种化合物的 MIC = 123.2 μM）。化合物 1 在细胞毒性和抗菌测定中均无活性。
