墨西哥瓦哈卡州两群体 HLA 系统的遗传多样性：瓦哈卡市和瓦哈卡农村。
Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca.
机构信息
Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico.
Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):553-556. doi: 10.1016/j.humimm.2019.07.278. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 636 Mexicans from the state of Oaxaca living in the city of Oaxaca (N = 151) and rural communities (N = 485), to obtain information regarding allelic and haplotypic frequencies. We found that the 13 most frequent haplotypes in Oaxaca are all of putative Native American origin. Admixture estimates revealed that the main genetic components in the state of Oaxaca are Native American (73.12 ± 2.77% by ML; 61.52% of Native American haplotypes) and European (17.36 ± 2.07% by ML; 20.69% of European haplotypes), and a relatively high African genetic component (9.52 ± 0.88% by ML; 8.94% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法，对来自瓦哈卡州的 636 名生活在瓦哈卡市（N=151）和农村社区（N=485）的墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因分析，以获得有关等位基因和单倍型频率的信息。我们发现，瓦哈卡州最常见的 13 个单倍型均源自美洲原住民。混合估计表明，瓦哈卡州的主要遗传成分是美洲原住民（最大似然法下的 ML 为 73.12±2.77%；61.52%的美洲原住民单倍型）和欧洲人（ML 为 17.36±2.07%；20.69%的欧洲人单倍型），以及相对较高的非洲遗传成分（ML 为 9.52±0.88%；8.94%的非洲人单倍型）。
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