墨西哥莫雷洛斯州两个群体（特诺奇提特兰的夸纳华卡和农村莫雷洛斯）的 HLA 系统遗传多样性。
Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos.
机构信息
Department of Developmental Genetics and Molecular Physiology, Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):557-559. doi: 10.1016/j.humimm.2019.07.289. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (N = 82) and rural communities (N = 30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in Morelos are Native American (60.43 ± 2.22% by ML; 53.57% of Native American haplotypes) and European (39.58 ± 3.70% by ML; 27.68% of European haplotypes), and a virtually absent African genetic component (0.00 ± 4.93% by ML; but 11.16% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法研究了 112 名来自墨西哥莫雷洛斯州、居住在库埃纳瓦卡市（N=82）和农村社区（N=30）的墨西哥人的 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获得有关等位基因和单倍型频率的信息。莫雷洛斯州最常见的单倍型包括七个美洲原住民、一个欧洲人、一个非洲人和一个亚洲人单倍型。混合估计显示，莫雷洛斯州的主要遗传成分是美洲原住民（ML 法为 60.43±2.22%；美洲原住民单倍型的 53.57%）和欧洲人（ML 法为 39.58±3.70%；欧洲人单倍型的 27.68%），几乎没有非洲遗传成分（ML 法为 0.00±4.93%；但非洲单倍型的 11.16%）。
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