墨西哥杜兰戈州两群体 HLA 系统的遗传多样性：杜兰戈市和农村杜兰戈。
Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango.
机构信息
Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany. Electronic address: http://www.shh.mpg.de/en.
出版信息
Hum Immunol. 2020 Sep;81(9):489-491. doi: 10.1016/j.humimm.2019.06.005. Epub 2019 Jun 11.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 479 Mexicans from the state of Durango living in Durango city (N = 153) and rural communities (N = 326), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Durango include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Durango are European (54.34 ± 1.68%) and Native American (45.66 ± 2.24%), while African genetic component was virtually absent (0.00 ± 2.03%). However, African haplotypes could be estimated at a proportion of 9.13%.
我们通过 PCR-SSP 基于分型的方法对来自杜兰戈州的 479 名生活在杜兰戈市（N=153）和农村社区（N=326）的墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因的研究，以获得有关等位基因和单倍型频率的信息。我们发现，在杜兰戈州发现的十个最常见的单倍型包括八个美洲原住民和两个欧洲单倍型。混合估计显示，杜兰戈州的主要遗传成分是欧洲（54.34±1.68%）和美洲原住民（45.66±2.24%），而非洲遗传成分几乎不存在（0.00±2.03%）。然而，非洲单倍型的比例可以估计为 9.13%。
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