墨西哥坎佩切两群体 HLA 系统的遗传多样性：坎佩切市和坎佩切农村。
Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche.
机构信息
Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Chemistry Faculty, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):566-568. doi: 10.1016/j.humimm.2019.07.281. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (N = 34) and rural communities (N = 47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Campeche are Native American (65.56 ± 0.96% by ML; 51.24% of Native American haplotypes), European (34.44 ± 10.94% by ML; 30.25% of European haplotypes), and a virtually absent African genetic component (0.00 ± 10.31% by ML; 9.26% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法，对来自坎佩切州的 81 名生活在坎佩切市（N=34）和农村社区（N=47）的墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因分析，以获取有关等位基因和单倍型频率的信息。我们发现，坎佩切州最常见的单倍型包括十个美洲原住民、三个欧洲人、一个非洲人和一个亚洲人单倍型。混合估计显示，坎佩切州的主要遗传成分是美洲原住民（最大似然法下为 65.56±0.96%；51.24%的美洲原住民单倍型）、欧洲人（最大似然法下为 34.44±10.94%；30.25%的欧洲人单倍型），以及几乎不存在的非洲遗传成分（最大似然法下为 0.00±10.31%；9.26%的非洲人单倍型）。
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