Textile Engineering Department of Amirkabir University of Technology Tehran, Iran.
Textile Engineering Department of Amirkabir University of Technology Tehran, Iran.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109768. doi: 10.1016/j.msec.2019.109768. Epub 2019 May 20.
Currently graphene-doped electrospun scaffolds have been a matter of great interest to be exploited in biomedical fields such as tissue engineering and drug delivery applications. The main objective of this paper is to evaluate the effect of graphene on biological properties of PCL/gelatin nanofibrous mats. SEM analysis was conducted to investigate the morphology of the electrospun nanofibers. The in-vitro cellular proliferation of PC12 cells on nanofibrous web was also investigated. Electrospun PCL/gelatin/graphene nanofibrous mats exhibited 99% antibacterial properties against gram-positive and gram-negative bacteria. Drug release studies indicated that the π-π stacking interaction between TCH and graphene has led to the far better controlled release of TCH from electrospun PCL/gelatin/graphene compared to PCL/gelatin nanofibrous scaffolds. These superior properties along with an improvement in hydrophilicity and biodegradation features has made the nanofibers a promising candidate to be used as electrically conductive scaffolds in neural tissue engineering as well as controlled drug delivery.
目前，掺杂石墨烯的电纺支架在组织工程和药物输送等生物医学领域的应用引起了极大的关注。本文的主要目的是评估石墨烯对 PCL/明胶纳米纤维毡生物性能的影响。通过 SEM 分析研究了电纺纳米纤维的形态。还研究了 PC12 细胞在纳米纤维网上的体外增殖情况。静电纺丝 PCL/明胶/石墨烯纳米纤维毡对革兰氏阳性菌和革兰氏阴性菌具有 99%的抗菌性能。药物释放研究表明，TCH 与石墨烯之间的 π-π 堆积相互作用导致 TCH 从静电纺丝 PCL/明胶/石墨烯中的释放得到了更好的控制，而与 PCL/明胶纳米纤维支架相比。这些优异的性能以及亲水性和生物降解性能的提高，使得纳米纤维成为神经组织工程中用作导电支架以及控制药物释放的有前途的候选材料。
