Jia Jue, Yu Fan, Wei Wei-Ping, Yang Ping, Zhang Ren, Sheng Yue, Shi Yong-Qin
Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.
Department of Library of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China.
World J Clin Cases. 2019 Jun 26;7(12):1444-1455. doi: 10.12998/wjcc.v7.i12.1444.
Currently, the findings about irisin as a novel myokine related to obesity are inconsistent in overweight/obese people. To our knowledge, no systematic analysis has been conducted to evaluate the relationship between irisin levels and overweight/obesity.
To evaluate the association between circulating irisin levels and overweight/obesity.
The Cochrane Library, MEDLINE, SCOPUS, and the ISI Web of Science were searched to retrieve all of the studies associated with circulating irisin levels and overweight/obesity. Standard mean difference values and 95% confidence intervals (CI) were estimated and pooled using meta-analysis methodology.
A total of 18 studies were included in our meta-analysis containing 1005 cases and 1242 controls. Our analysis showed that the circulating irisin level in overweight/obese people was higher than that in overall healthy controls (random effects MD = 0.63; 95%CI: 0.22-1.05; = 0.003). In the subgroup analysis by ethnicity, the irisin level was higher in overweight/obesity people than that in controls in Africa (random effects MD = 3.41; 95%CI: 1.23-5.59; < 0.05) but not in European, Asian, or American populations. In addition, in a subgroup analysis by age, the results showed that obese children exhibited a higher irisin level than controls (random effects MD = 0.86; 95%CI: 0.28-1.43; < 0.05).
This meta-analysis provides evidence that circulating irisin is higher in obese individuals compared to healthy controls and it is important to identify the relationship between circulating irisin levels and overweight/obesity in predicting overweight/obesity.
目前，关于鸢尾素作为一种与肥胖相关的新型肌动蛋白的研究结果在超重/肥胖人群中并不一致。据我们所知，尚未进行系统分析来评估鸢尾素水平与超重/肥胖之间的关系。
评估循环鸢尾素水平与超重/肥胖之间的关联。
检索Cochrane图书馆、MEDLINE、SCOPUS和ISI科学网，以获取所有与循环鸢尾素水平和超重/肥胖相关的研究。使用荟萃分析方法估计并汇总标准平均差值和95%置信区间（CI）。
我们的荟萃分析共纳入18项研究，包括1005例病例和1242例对照。我们的分析表明，超重/肥胖人群的循环鸢尾素水平高于总体健康对照人群（随机效应MD = 0.63；95%CI：0.22 - 1.05；P = 0.003）。在按种族进行的亚组分析中，超重/肥胖人群的鸢尾素水平高于非洲对照组（随机效应MD = 3.41；95%CI：1.23 - 5.59；P < 0.05），但在欧洲、亚洲或美洲人群中并非如此。此外，在按年龄进行的亚组分析中，结果显示肥胖儿童的鸢尾素水平高于对照组（随机效应MD = 0.86；95%CI：0.28 - 1.43；P < 0.05）。
这项荟萃分析提供了证据，表明肥胖个体的循环鸢尾素水平高于健康对照，并且在预测超重/肥胖时确定循环鸢尾素水平与超重/肥胖之间的关系很重要。
