Centers for Disease Control and Prevention,Atlanta,GA.
Mission Rabies,Cranborne,UK.
Epidemiol Infect. 2019 Jan;147:e247. doi: 10.1017/S0950268819001158.
Dogs harbor numerous zoonotic pathogens, many of which are controlled through vaccination programs. The delivery of these programs can be difficult where resources are limited. We developed a dynamic model to estimate vaccination coverage and cost-per-dog vaccinated. The model considers the main factors that affect vaccination programs: dog demographics, effectiveness of strategies, efficacy of interventions and cost. The model was evaluated on data from 18 vaccination programs representing eight countries. Sensitivity analysis was performed for dog confinement and vaccination strategies. The average difference between modelled vaccination coverage and field data was 3.8% (2.3%-5.3%). Central point vaccination was the most cost-effective vaccination strategy when >88% of the dog population was confined. More active methods of vaccination, such as door-to-door or capture-vaccinate-release, achieved higher vaccination coverage in free-roaming dog populations but were more costly. This open-access tool can aid in planning more efficient vaccination campaigns in countries with limited resources.
狗携带许多人畜共患病病原体，其中许多病原体可以通过疫苗接种计划来控制。在资源有限的情况下，这些计划的实施可能会很困难。我们开发了一个动态模型来估计疫苗接种覆盖率和每只狗的接种成本。该模型考虑了影响疫苗接种计划的主要因素：狗的人口统计学特征、策略的有效性、干预措施的效果和成本。该模型使用来自 8 个国家的 18 个疫苗接种计划的数据进行了评估。对狗的圈养和疫苗接种策略进行了敏感性分析。模型预测的疫苗接种覆盖率与实地数据的平均差异为 3.8%（2.3%-5.3%）。当 >88%的狗被圈养时，中心点疫苗接种是最具成本效益的疫苗接种策略。在自由放养的狗群中，采用上门或捕捉-接种-释放等更积极的疫苗接种方法可以提高疫苗接种覆盖率，但成本更高。这个开放获取的工具可以帮助资源有限的国家规划更有效的疫苗接种运动。
