Chemistry of Medicinal Plants Department, National Research Centre, Dokki, Giza, Egypt.
Chemistry of Natural and Microbial Products Department, National Research Centre, Giza, Egypt.
Nat Prod Res. 2021 Jun;35(12):1959-1967. doi: 10.1080/14786419.2019.1647430. Epub 2019 Jul 31.
is widely used in traditional medicines for the treatment of several diseases. From the aerial parts organic extract of , two new compounds, 1,3,8-trihydroxyeudesm-4-en-7,11H-12,6-olide () and 5---glucopyranosyloxy-7-methoxy-6H-benzopyran-2-one (), respectively, together with five known metabolites: 3,8-dihydroxygermacr-4(15),9(10)-dien-7,11H,12,6-olide (), 1,8-dihydroxy-11,13-dihydrobalchanin (), 11-epiartapshin (), tomenin () and benzoic acid, -(--glucopyranosyloxy)-methyl ester (), were isolated and identified. The chemical structures were proven depending upon spectroscopic analysis, including 1 D/2D NMR as and ESI-MS. Compound inhibited Gram-positive bacteria and Compounds and exhibited antibacterial activity against both gram-positive and gram-negative bacteria.
在传统医学中，被广泛用于治疗多种疾病。从该植物的地上部分的有机提取物中，分离得到了两个新化合物，分别为 1,3,8-三羟基-桉叶-4-烯-7,11H-12,6-内酯（）和 5----葡萄糖吡喃糖基--7-甲氧基--6H-苯并吡喃--2-酮（），以及另外 5 个已知代谢产物：3,8-二羟基-大根香叶-4(15),9(10)-二烯-7,11H,12,6-内酯（），1,8-二羟基-11,13-二氢巴尔卡宁（），11-表阿替普辛（），tomenin（）和苯甲酸，-(--葡萄糖吡喃糖基）-甲酯（）。通过波谱分析（包括 1D/2D NMR 和 ESI-MS）鉴定了这些化合物的化学结构。化合物 抑制革兰氏阳性菌，化合物 和 对革兰氏阳性菌和革兰氏阴性菌均具有抗菌活性。
