Laboratory for Oxidative Stress, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
Laboratory for Molecular Pathology, Department of Pathology and Cytology, University Hospital Centre Zagreb, Salata 10, 10000 Zagreb, Croatia.
Cells. 2019 Jul 30;8(8):793. doi: 10.3390/cells8080793.
The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular functions through redox signaling. In the majority of cases, metabolic demands, along with other stimuli, are vital for ROS formation and their actions. In this review, we focus on the role of ROS in regulating cell functioning and communication among themselves. The relevance of ROS in therapy concepts is also addressed here.
在过去的四十年中，活性氧（ROS）的重要性逐渐得到认可。最初，ROS 被认为是有害氧化应激的有害产物，但此后，人们对 ROS 的认识也得到了提升，现在 ROS 也被认为是通过氧化还原信号调节生理细胞功能所必需的。在大多数情况下，代谢需求以及其他刺激对于 ROS 的形成及其作用至关重要。在这篇综述中，我们重点关注 ROS 在调节细胞功能和细胞间通讯中的作用。本文还讨论了 ROS 在治疗概念中的相关性。
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