Endocrinology and Nephrology Unit, CHU de Québec-Université Laval Research Center, 2705 Laurier Boulevard, G1V 4G2, Québec, Canada.
Department of Kinesiology, Faculty of Medicine, Université Laval, 1050 de la Médecine Avenue, G1V 0A6, Québec, Canada.
Mol Nutr Food Res. 2019 Oct;63(19):e1900126. doi: 10.1002/mnfr.201900126. Epub 2019 Aug 7.
Metabolomics is increasingly used to identify biomarkers of diet or chronic diseases, such as type 2 diabetes. Yet, metabolite signatures following dairy intake in hyperinsulinemic subjects have not been identified. The objective is to evaluate the effects of a high dairy diet (HD) for 6 weeks (4 servings or more per day), compared with an adequate dairy diet (AD) (2 servings or less per day), on serum metabolite profiles in hyperinsulinemic adults.
In this crossover trial, subjects are randomized to HD or AD for 6 weeks. Serum metabolites are assessed using GC/MS. Twenty-six subjects completed the study. Levels of pentadecanoic acid, tyrosine and lathosterol are increased in HD, while 1,5-anhydrosorbitol, myo-inositol, 3-aminoisobutyric acid and beta-sitosterol are decreased (p < 0.05). Sorbitol levels are increased after AD, while hexanoic acid, lauric acid, l-kynurenine, methionine, and benzoic acid levels are reduced (p < 0.05). Histidine, caprylic acid, nonanoic acid, decanoic acid, lauric acid, heptadecanoic acid, and benzoic acid levels are increased in HD compared to AD, while malic acid levels are increased in AD compared with HD (p < 0.05).
Higher dairy products intake modifies metabolite profiles in hyperinsulinemic subjects.
代谢组学越来越多地用于识别饮食或慢性疾病（如 2 型糖尿病）的生物标志物。然而，高胰岛素血症患者摄入乳制品后的代谢物特征尚未确定。本研究旨在评估高脂乳制品饮食（HD，每天 4 份或以上）与适量乳制品饮食（AD，每天 2 份或以下）对高胰岛素血症成年人血清代谢谱的影响。
在这项交叉试验中，受试者随机分为 HD 或 AD 组，进行 6 周的饮食干预。采用 GC/MS 评估血清代谢物。26 名受试者完成了这项研究。HD 组中十五烷酸、酪氨酸和羊毛甾醇的水平升高，而 1,5-脱水山梨醇、肌醇、3-氨基异丁酸和β-谷甾醇的水平降低（p<0.05）。AD 组中山梨醇水平升高，而己酸、月桂酸、L-犬尿氨酸、蛋氨酸和苯甲酸水平降低（p<0.05）。与 AD 相比，HD 组中组氨酸、辛酸、壬酸、癸酸、月桂酸、十七烷酸和苯甲酸的水平升高，而 AD 组中苹果酸的水平升高（p<0.05）。
高乳制品摄入可改变高胰岛素血症患者的代谢物谱。
