痰液中铜绿假单胞菌吩嗪色素的测定及其对呼吸道上皮细胞痰液溶解毒性作用的评估
Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium.
作者信息
Wilson R, Sykes D A, Watson D, Rutman A, Taylor G W, Cole P J
机构信息
Department of Thoracic Medicine, Brompton Hospital, London, United Kingdom.
出版信息
Infect Immun. 1988 Sep;56(9):2515-7. doi: 10.1128/iai.56.9.2515-2517.1988.
Abstract
The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. The concentrations measured were each sufficient to inhibit ciliary beating in vitro and contributed a significant proportion of sol phase toxicity for respiratory epithelium.
摘要
通过高压液相色谱法从13例囊性纤维化或支气管扩张且被铜绿假单胞菌定植患者中的9例痰液溶解相中分离出吩嗪色素绿脓菌素和1-羟基吩嗪。所测得的浓度均足以在体外抑制纤毛摆动，并对呼吸道上皮细胞溶解相毒性有显著贡献。
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本文引用的文献
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Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro.铜绿假单胞菌产生的绿脓菌素和1-羟基吩嗪在体外可抑制人呼吸道纤毛的摆动。
J Clin Invest. 1987 Jan;79(1):221-9. doi: 10.1172/JCI112787.
8
Purification and structural analysis of pyocyanin and 1-hydroxyphenazine.绿脓菌素和1-羟基吩嗪的纯化及结构分析
Eur J Biochem. 1986 Sep 1;159(2):309-13. doi: 10.1111/j.1432-1033.1986.tb09869.x.
9
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10
Studies on the mechanism of T cell inhibition by the Pseudomonas aeruginosa phenazine pigment pyocyanine.铜绿假单胞菌吩嗪色素绿脓菌素对T细胞抑制机制的研究
J Immunol. 1987 May 15;138(10):3481-7.
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