Health and Environment Microbiology Laboratory, Doctoral School of Sciences and Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon.
LIA Laboratory, Doctoral School in Science & Technology, Lebanese University, Tripoli - Lebanon.
Int J Antimicrob Agents. 2019 Dec;54(6):771-779. doi: 10.1016/j.ijantimicag.2019.07.012. Epub 2019 Jul 30.
Bacteriocins from lactic acid bacteria (LAB) are successfully applied as natural alternatives to food preservation and to antibiotics; however, information on these antimicrobial peptides (AMPs) is scattered through the literature and databases. Therefore, we developed the LABiocin database, a specialized database on LAB bacteriocins. The database was stored and compiled using MySQL with NetBeans IDE as the platform. Important data are compiled, including bacteriocin name, class, amino acids and nucleic acid sequences, if available. Target microorganisms, origin, status of the producing strains and their culture conditions and extraction and purification methods are also included in this new database. A phylogenetic tree for the mature peptide bacteriocin sequences has also been created. LABiocin is an interactive database with a user-friendly interface that integrates several tools and services and comprises up to 517 LAB bacteriocins. Besides data searching tools, a BLAST tool was integrated into the database to enable the user to perform a homology search against mature peptide sequences. Users can be linked to other databases that contain additional information, particularly about predicted bacteriocin structure and mechanisms of action. The LABiocin database enables comprehensive functional analysis of this special group of AMPs. This would be useful in food preservation and food safety applications and would also have substantial implications for development of new drugs for medical use. LABiocin database is available at labiocin.net.
乳酸菌（LAB）细菌素被成功地应用于食品保鲜和抗生素的天然替代品；然而，这些抗菌肽（AMPs）的信息分散在文献和数据库中。因此，我们开发了 LABiocin 数据库，这是一个专门针对 LAB 细菌素的数据库。该数据库使用 MySQL 存储和编译，使用 NetBeans IDE 作为平台。重要的数据包括细菌素名称、类别、氨基酸和核酸序列（如果有）。目标微生物、来源、生产菌株的状态及其培养条件和提取及纯化方法也包括在这个新的数据库中。还创建了成熟肽细菌素序列的系统发育树。LABiocin 是一个具有用户友好界面的交互式数据库，集成了几个工具和服务，包含多达 517 种 LAB 细菌素。除了数据搜索工具外，还将 BLAST 工具集成到数据库中，使用户能够对成熟肽序列执行同源搜索。用户可以链接到包含其他信息的其他数据库，特别是关于预测细菌素结构和作用机制的信息。LABiocin 数据库能够对这组特殊的 AMPs 进行全面的功能分析。这在食品保鲜和食品安全应用中非常有用，也将对开发用于医疗用途的新药产生重大影响。LABiocin 数据库可在 labiocin.net 上获得。
