Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura 10250, Sri Lanka.
Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura 10250, Sri Lanka.
J Microbiol Biotechnol. 2019 Nov 28;29(11):1841-1851. doi: 10.4014/jmb.1904.04032.
Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried fruit rinds of . In this study, garcinol has successfully used to reduce silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs). The formation and the structure of G-AgNPs were confirmed by UV-visible spectroscopy, transmission electron microscopy and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of garcinol and G-AgNPs were investigated by well diffusion assays, broth micro-dilution assays and time-kill kinetics studies against five microbial species, including (ATCC 25923), (ATCC 27853), (ATCC 25922), (ATCC 10231) and clinically isolated methicillin-resistant (MRSA). The formation of G-AgNPs is a promising novel approach to enhancing the biological activeness of silver nanoparticles, and to increase the water solubility of garcinol which creates a broad range of therapeutic applications.
姜黄素，一种著名的药用植物化学物质，从. 的干果皮中提取和分离得到。在这项研究中，姜黄素成功地用于将银离子还原为银，以合成姜黄素封端的银纳米粒子（G-AgNPs）。通过紫外-可见光谱、透射电子显微镜和傅里叶变换红外（FTIR）光谱证实了 G-AgNPs 的形成和结构。通过平板扩散法、肉汤微量稀释法和时间杀伤动力学研究，研究了姜黄素和 G-AgNPs 对五种微生物的抗菌活性，包括 （ATCC 25923）、 （ATCC 27853）、 （ATCC 25922）、 （ATCC 10231）和临床分离的耐甲氧西林金黄色葡萄球菌（MRSA）。G-AgNPs 的形成是一种有前途的新方法，可以提高银纳米粒子的生物活性，并增加姜黄素的水溶性，从而创造广泛的治疗应用。
