Chen Qin, Boeve Bradley F, Senjem Matthew, Tosakulwong Nirubol, Lesnick Timothy G, Brushaber Danielle, Dheel Christina, Fields Julie, Forsberg Leah, Gavrilova Ralitza, Gearhart Debra, Graff-Radford Jonathan, Graff-Radford Neill R, Jack Clifford R, Jones David T, Knopman David S, Kremers Walter K, Lapid Maria, Rademakers Rosa, Syrjanen Jeremy, Boxer Adam L, Rosen Howie, Wszolek Zbigniew K, Kantarci Kejal
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Alzheimers Dement (N Y). 2019 Jul 30;5:338-346. doi: 10.1016/j.trci.2019.05.010. eCollection 2019.
The aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau () mutation carriers.
mutation carriers (n = 14; 10 asymptomatic, 4 converters from asymptomatic to symptomatic) and noncarriers (n = 13) underwent structural magnetic resonance imaging and were followed annually with a median of 9.2 years. Longitudinal changes in lobar atrophy were analyzed using the tensor-based morphometry with symmetric normalization algorithm.
The rate of temporal lobe atrophy in asymptomatic mutation carriers was faster than that in noncarriers. Although the greatest rate of atrophy was observed in the temporal lobe in converters, they also had increased atrophy rates in the frontal and parietal lobes compared to noncarriers.
Accelerated decline in temporal lobe volume occurs in asymptomatic mutation carriers followed by the frontal and parietal lobe in those who have become symptomatic. The findings have implications for monitoring the progression of neurodegeneration during clinical trials in asymptomatic mutation carriers.
本研究旨在调查无症状微管相关蛋白tau（）突变携带者的脑叶萎缩率。
突变携带者（n = 14；10例无症状，4例从无症状转变为有症状）和非携带者（n = 13）接受了结构磁共振成像检查，并每年进行随访，中位随访时间为9.2年。使用基于张量的形态测量法和对称归一化算法分析脑叶萎缩的纵向变化。
无症状突变携带者的颞叶萎缩率高于非携带者。虽然在转变者中观察到最大的萎缩率出现在颞叶，但与非携带者相比，他们的额叶和顶叶萎缩率也有所增加。
无症状突变携带者的颞叶体积加速下降，随后有症状者的额叶和顶叶也出现萎缩。这些发现对于在无症状突变携带者的临床试验中监测神经退行性变的进展具有重要意义。
