Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, 300173 Timisoara, Romania.
Center for Translational Research and Systems Medicine, "Victor Babes" University of Medicine and Pharmacy, 300173 Timisoara, Romania.
Dis Markers. 2019 Jul 17;2019:2568069. doi: 10.1155/2019/2568069. eCollection 2019.
Arterial stiffness and arterial age provide valuable prognostic cardiovascular information. The present study aimed at assessing the levels of vitamin D, high-sensitivity C-reactive protein (hsCRP), low-density lipoprotein cholesterol (LDL), and oxidized LDL (oxLDL) in a group of middle-aged hypertensive patients and their relationship with pulse wave velocity (PWV), central blood pressure, and early arterial aging (EAA), respectively. A total of 56 patients, aged 48 ± 6 years, 57% males, with hypertension and high normal blood pressure (HNBP), were investigated using a Mobile-O-Graph, to assess central and peripheral blood pressure, PWV, and arterial age. Additionally, hsCRP, LDL, oxLDL, and 25-hydroxy vitamin D3 were assessed. PWV, 25-hydroxy vitamin D3, hsCRP, oxLDL, and LDL levels were 7.26 ± 0.69 m/s, 25.99 ± 11.17 microg/l, 0.48 ± 0.44 mg/dl, 261.37 ± 421 ng/ml, and 145.73 ± 39.53 mg/dl, respectively. Significant correlations were obtained between oxLDL and pulse pressure amplification (rS = -0.347, = 0.028) and between hsCRP and LDL levels with PWV and EAA, respectively. ROC curve analysis revealed that hsCRP is a sensitive and specific predictor of EAA and increased PWV values. Concluding, vitamin D deficiency and increased hsCRP and LDL values are very common, and high oxidized LDL is related to pulse pressure amplification in patients with elevated blood pressure. Vitamin D level and high-sensitivity C-reactive protein and LDL provide valuable information in middle-aged hypertensive and HNBP patients related to arterial stiffness and early arterial aging, but only hsCRP is a sensitive predictor of EAA and PWV.
动脉僵硬度和动脉年龄提供了有价值的心血管预后信息。本研究旨在评估一组中年高血压患者的维生素 D、高敏 C 反应蛋白 (hsCRP)、低密度脂蛋白胆固醇 (LDL) 和氧化型低密度脂蛋白 (oxLDL) 水平，以及它们与脉搏波速度 (PWV)、中心血压和早期动脉老化 (EAA) 的关系。共纳入 56 名年龄为 48 ± 6 岁、57%为男性的高血压和高血压前期患者，使用 Mobil-O-Graph 评估中心和外周血压、PWV 和动脉年龄。此外，还评估了 hsCRP、LDL、oxLDL 和 25-羟维生素 D3。PWV、25-羟维生素 D3、hsCRP、oxLDL 和 LDL 水平分别为 7.26 ± 0.69 m/s、25.99 ± 11.17 μg/l、0.48 ± 0.44 mg/dl、261.37 ± 421 ng/ml 和 145.73 ± 39.53 mg/dl。oxLDL 与脉压放大率(rs=-0.347，P=0.028)显著相关，hsCRP 与 LDL 水平与 PWV 和 EAA 显著相关。ROC 曲线分析显示，hsCRP 是 EAA 和升高的 PWV 值的敏感和特异性预测因子。结论：维生素 D 缺乏以及 hsCRP 和 LDL 水平升高非常常见，高氧化型 LDL 与高血压患者的脉压放大率相关。维生素 D 水平、高敏 C 反应蛋白和 LDL 可提供与动脉僵硬度和早期动脉老化相关的有价值信息，但只有 hsCRP 是 EAA 和 PWV 的敏感预测因子。
